SHBG serves an important role in helping mediate the transfer of testosterone into the cells for its primary function, cell growth and repair. Testosterone Cypionate is our preferred choice of ester for Gold Standard TRT. Total testosterone is not bioavailable, it is simply the precursor to the bioavailable androgens, free testosterone, oestradiol and dihydrotestosterone. For a better experience, please enable JavaScript in your browser before proceeding. 140mg/week is more along the lines of TRT for someone in the muscle game, its basically a satisfactory dose for someone who cultivated receptors from higher … I take 100mg Monday with the rest Thursday mornings . Trying to get that SHBG down to get along with less Test, but atm im increasing to 30mg of Test E ed. You cannot predetermine that number based on the current data. JavaScript is disabled. I've read some testimonies as well as listen to some on youtube, where guys talked about if they had to do all over again, they'd slow down in the gym. The above data demonstrates that the current recommendations regarding dose and injection frequency do not achieve this. According the British National Formulary, a single dose of 250mg Testosterone Enanthate should be injected every 2-3 weeks(1). In view of our experiences with Nebido, we looked to the American model for managing TDS. I mean honestly! Context: Testosterone (T) is commonly administered intramuscularly to treat hypogonadal males and female-to-male (FTM) transgender patients. Dispelling The Myths: TRT & Cardiovascular Health, Dispelling the Myths: Prostate Cancer & Testosterone Replacement Therapy (TRT), Microdosing TRT – The Future of Testosterone Replacement Therapy. This has me just above top end of ‘normal’. 5 grams once daily Apply 60 mg once daily, subsequent application adjusted according to response; maximum 80 mg per day. If the injection frequency is too long, you can reach a steady state, yet that term will be a relative one and you will still notice peaks and troughs as the testosterone is metabolised and excreted by the kidneys as conjugates of glucuronic and sulfuric acids in urine at a high rate. Due to the long-acting nature of this compound, a loading dose is recommended at six weeks. So I tried 3x/week. As already discussed, the aim of TRT and TOT is to achieve sustainable stable levels that bring about, not only the correct total testosterone level, but also optimal levels of the bioavailable markers; free testosterone, oestradiol and dihydrotestosterone. However, these injections can involve significant discomfort and may require arrangements for administration by others. I've always had some acne, even natural, on my shoulders and back and sometimes on my face. The Men's Health Clinic Through clinical experience, I have become a huge proponent of daily subcutaneous Testosterone Cypionate injections, not only to achieve stable male androgen levels, but also to mimic natural physiology. I know some guys who go subq with tren a, i cant remember their reasoning for this but they liked it. Currently on trt dose of 200mg cyp per week(100mg e3.5d) + 800mg hcg. The Cmax 7 days after the first injection was noted to be 38 nmol/L, this rose to 50nmol/l after the 6-week loading dose was administered. Any … Gold Standard TRT includes Human Chorionic Gonadotropin (HCG) alongside testosterone. This is an arbitrary discussion since we know there are health benefits in having a testosterone above 19nmol/l(7). I do 1 1ml shot (200mg Test C) sub q a week in the stomach area, started to use the “love handles” lately, seems fine so far, less tender than stomach to me. Subcutaneous test prop or trest ace as base? Why SubQ Better Going under the skin saves you from approximately 500 potentially damaging intramuscular injections every decade. Interested to see how your numbers are affected. They were using short-acting esters, such as enanthate and cypionate (both are interchangeable), and were achieving stable levels that were backed up with a noted improvement in their symptoms. As an aside, Sustanon is an interesting blend of esters, it was designed to achieve stable levels. A recent study ‘Daily subcutaneous testosterone for management of testosterone deficiency’ demonstrated consistent and statistically significant increases in the three testosterone values, total testosterone, free serum testosterone, and direct free testosterone, suggesting that the daily subcutaneous testosterone therapy method used for the patients included in the study has … Esters are attached to the testosterone molecule by a process called hydrolysis. If my test numbers are just as good with the test eth and I feel good, I'll probably stick with that for a while. SHBG which binds to testosterone is often the determining factor in deciding injection frequency. Unfortunately, this raised a further set of problems. You must first understand that the total testosterone level is not a true marker by which qualitative and quantitive symptoms can be gauged. In some patients with high-normal Sex-Hormone Binding Globulin levels, it is possible to achieve stable levels with a less intensive injection frequency, however there is a reported qualitative difference in well-being with daily injections. Testosterone that is injected via SubQ needles is absorbed by the body and into the bloodstream ‘more slowly’ than that of IM injections so the frequency and amount are different. First, let’s have a quick understanding of what each term means and what it means to us as trans men.. Self-Injecting: Some people, for one reason … Whilst oestrogen is incredibly important in cognitive function, mood, libido, fertility, cardiovascular health and maintaining bone strength, too much is as bad as too little. Currently on trt dose of 200mg cyp per week(100mg e3.5d) + 800mg hcg. Anything under 200 I do 1 shot and when I go over I’ll split it and do IM in the delts. Whilst topical application of testosterone cream or gel remains a reasonable choice of delivery method, there are potential limitations to its efficacy due to inconsistent absorption with the skin barrier. Why SubQ Better1. You can also use the same needle to fill your syringe and administer the dose when going subQ and you don't even need to aspirate. This essentially negated the argument for a loading dose with the next injection interval being twelve weeks. We all have a unique genetic blue-print, no one person’s physiology is identical to that of another. Injection intervals were shortened further over time for our regular patients until reasonable trough levels were achieved. Did you know the word "sandwich" is named for a person? It is difficult to achieve stable levels on Sustanon and providers often resort to an aromatase inhibitor or ‘third leg of TRT’ to reduce oestrogen. I've had a few periods of time where I did daily shots in the glute with slinpins, from 150mg all the way to 600mg per week, I've also done 1/2ml 1x per week with a half inch pin in the glute for months on end as trt, I dont really notice any difference for the most part but when I did the daily subq shots as a cycle I had significantly less acne then previously with the same total … Did You Know? My buddies do daily trt with insulin pins around their belly button. In response, we decreased the interval between the loading dose and the 3rd dose to ten weeks for new patients. That's funny you mention the acne.. We are the first private medical clinic in the UK to import Testosterone Cypionate in the UK for our patients. The temporary issue of a few weeks of some breast tissue swelling, nipple tenderness, water retention and acne was bad enough, but to have sustained symptoms was intolerable. Definizione e significato del termine substrato Drugs for visceral body fat vs subcutaneous body fat. Along with TRT treatment, I've also started back in the gym after a 6 month COVID layoff.

No issues. The aim of Testosterone Replacement Therapy (TRT) is to restore your androgen levels to within normal physiological parameters. As already mentioned, there is individual variation in drug metabolism of the different esters and there is no defined optimal testosterone level, so you cannot apply a standard fixed dose and frequency of injection to achieve stability. Intramuscular injections are administered into the muscle tissue, which is located below the skin and subcutaneous tissue. Error bars indicate standard deviations. Going under the skin saves you from approximately 500 potentially damaging intramuscular injections every decade.2. The current UK reference range of 12-29 nmol/l is very non-specific, doctors do not take age into consideration despite knowing there is an age-related decline in testosterone. Substrato: vedi sostrato. It was also noted that testosterone levels returned to baseline typically after 2 weeks, so the suggested 3-week injection frequency would be ineffective in rising baseline figures. For me, there is about a 400ng/dL difference between the two methods (8-900 ng/dL vs 4-500 ng/dL - sub q being the lower number). However, the high Benzoyl Alcohol content of Sustanon which can cause post injection pain (PIP) makes that a rather unappealing proposition. More frequent smaller doses are often better at achieving actual steady levels. There were a few outliers who had residual pituitary function, these patients were noted to have a primary hypogonadism, their total testosterone levels were still only just above baseline. It is also the preferred choice of ester  in the USA, where Testosterone Deficiency and TRT is more commonly and widely accepted. Combining Evidence-Based Medicine & Clinical Expertise, To Give You A Much Needed Perspective. subq shots are easy and painless (with gh or peps), idk about gear but if its anything like gh and its not super painful … I recently learned subcutaneous testosterone injections are possible. That’s right, the lunchbox special enveloping all food groups between two slices of bread is named for the 4th Earl of Sandwich, an English aristocrat who lived in the 1700s. The journey takes him to Hanli Pazar where he encounters with leaders of The Cavdar Tribe- the most powerful in western Anatolia. I've had a few periods of time where I did daily shots in the glute with slinpins, from 150mg all the way to 600mg per week, I've also done 1/2ml 1x per week with a half inch pin in the glute for months on end as trt, I dont really notice any difference for the most part but when I did the daily subq shots as a cycle I had significantly less acne then previously with the same total dose 1-2 week intramuscular, I'm actually rotating delts and gluts right now with a 25g 1/2 and have been the past few months so technically ever other pin is sub q. Subq never worked for me..I feel best with injection in the side delts.. Therefore, to titrate your optimal dose and frequency, it is sensible to use only one variable. So a direct comparison to Sustanon and Testogel, hence the marketing. Nebido (Testosterone Undeconate) was the UK licenced drug for the treatment of Testosterone Deficiency Syndrome. I started TRT on 6/17. … How to use substrate in a sentence. It also makes sense that the action of this variable should be predictable, something that has been demonstrated with testosterone enanthate; oestradiol and DHT levels exhibit saturable increases with increased dose(9). Even with this method, there are two different approaches – subcutaneous (SubQ) or Intramuscular (IM). I started TRT ~12 weeks ago at 100mg/week 1 shot subq in the stomach, upped 3 weeks ago to 80mg/2x week subq. I dont think I have ever had bloodwork on strictly sub q shots so I dont know how it effects me levels wise, I just notice I feel good either way and have less acne with smaller more frequent injections in which I use a 1/2in slin pin or 25g 1/2 in so I'm sure when I'm hitting glutes it's going sub q if I dont have that pin completely buried, I just realized I've been replying to 2 different threads with a similar topic, thought it was all the same 1. I want to change to daily subQ to optimize TRT (Jay Campbell). The aim of our study was to investigate whether daily intake of two different dosages of arginine asparate during four weeks affects selected parameters of overtraining syndrom … For testosterone replacement therapy (TRT) and many other medical treatments, two main types of injections are Intramuscular injections and Subcutaneous injections. TRT must be personalised as we are all biologically unique, you cannot have a one size fits all approach to hormonal health. I have no experience of IM to compare to though. Please click on the links for further information. Injecting your testosterone subcutaneously involves the use of a small gauge needle (25 gauge half-inch, or 26 gauge 3/8 inch if you're very lean), thus making it feasible to give yourself two injections per week, which allows for a more even and … Dashed lines denote upper and lower limits of normal range. The vast majority of men had numbers not too dissimilar to pre-treatment levels, along with pituitary suppression of Lutenising Hormone (LH) and Follicle Stimulating Hormone (FSH), something that is expected on TRT. THANKsJust bear in mind the amount of wastage you'll encounter doing daily. When choosing a testosterone, it’s important to understand how long it will typically take to achieve a ‘steady state’. Steady-state mean serum levels of testosterone, bioavailable testosterone (T), dihydrotestosterone (DHT), and estradiol in thirty-three hypogonadal 22- to 65-year-old men given 200 mg of intramuscular testosterone enanthate every 2 weeks. I haven’t gone into detail on The Benefits of using HCG with TRT or our TRT Management Guidelines as these have been covered in previous blogs. Never done IM so I can't say it's the subq vs IM but maybe my hormones were so screwed (had 3x blood work to confirm my total T levels were about 100 under the lower reference and free T about 6.8 range being 8.1-25), Pre trt my T levels were ****, like 190 total and 7 or so free with estrogen slightly above the upper range.. since starting trt obviously T levels are up, but my estrogen has remained consistent without an AI so I'm guessing the improved T to E ratio is what has really helped me. However, the increased fluidity of the olive oil solvent in Testosterone Cypionate, alongside its low concentration of Benzoyl Alcohol preservative, makes Cypionate a preferable choice for subcutaneous injections. He explained that subq tends to be a slower release and can possibly help keep levels more stable, it also can help with scar tissue buildup, and not from my doc but I've heard anecdotally because of the slower release it can help with aromatization. 140mg/week is more along the lines of TRT for someone in the muscle game, its basically a satisfactory dose for someone who cultivated receptors from higher … Achieving stable levels is all about tailoring injection dose and frequency according to need, and titrating that level up or down according to both qualitative and quantitve markers.

The primary hormone for male characteristic development, including body hair and muscular development, made in the testes or synthetically created in a lab.Testosterone Enanthate. I Got my bloods today from 175mg of Test E (pharma) weekly, daily subq. Hi all. It is recognised that there is variance of the peak and trough levels between individuals(6) and so the data cannot apply to everybody. According the British National Formulary, a single dose of 250mg Testosterone Enanthate should be injected every 2-3 weeks, . Subcutaneous injections (sometimes called “SubQ”) are administered into the subcutaneous fat tissue, just below the skin. At TRT World, audiences can expect balanced, in-depth reporting with a focus on global responsibility. Do I just divide 200/7 = 28.7mg T and inject daily SUBQ starting Monday ? Topic of the Week: The Single Best Supplement You've Taken. For test it has to be small shots, like .3mls max, if your on trt and your shooting 1ml ew for 200mgs or so youd have to split your shots into 3 ew subq. Nebido contains the long undecanoic acid ester.

140mg/week is more along the lines of TRT for someone in the muscle game, its basically a satisfactory … In theory, this blend of esters with varying half-life’s was designed to reduce the peaks and troughs associated with the metabolism of the testosterone. I watched a video by MorePlatesMoreDates on youtube saying that he takes his TRT SubQ in order to avoid test peaks and lows. Thats the only way i could ever imagine doing it that frequently, the IM shots are too unpleasant (I use a 25 g syringe for the IM shots) ... More posts from the trt community. Adapted, with permission, from Dobs et al.7(3). Testosterone Enanthate contains the carboxylic acid ester, enanthoic acid. Sustanon is prescribed because it’s cheap, dirt cheap, sometimes you just get what you pay for. Usually backload several weeks at once, 0.5ml (125mg test e or c) each insulin syringe then add 0.15ml hcg (350iu) and inject once a week in two shots 0.325ml was each subq and not had any problems and can’t tell any difference in how I feel from going IM. See more. According to the manufacturer, a single injection of 250mg leads to an increase in total plasma testosterone between 44.5-60.4 nmol/l (Cmax), which is reached within 0.5 – 5 days post injection. Levels then return to baseline after approximately 21 days, longer than Enanthate, presumably due to the longer half-life of the decanoate ester(4). But I am also getting older which seems to effect that. Gold Standard TRT. daily subq trt September 15, 2020 By Leave a Comment By brooklynheight in forum Anabolic Steroid Forum 80mgs/week is a good TRT dose for those looking for at long term hypogonadism replacement treatment, coming from much lower levels over long period of time 80mg/week will be felt and make a difference in life quality. Another protein to be taken into consideration is albumin, formed in the liver, which has a weaker affinity for testosterone so still reduces the free testosterone level. Despite this, patients were still complaining of peaks and troughs. 168 Ringwood Road Perhaps it made sense after a few glasses of scotch! The primary aim of TRT is to achieve stable hormone levels within the body so that homeostasis is maintained. Steady state according to the different esters available: The aim of dosing is to build up the plasma concentration of testosterone so that it achieves an optimal level according to your genetics, physiology and utilisation. Accordingly, subQ injections also cause less pain and irritation than IM shots. Objective: We assessed whether T could be administered effectively and safely subcutaneously as an alternative to … Dans le cadre de la commercialisation du HRDP ®1, support en verre spécial destiné aux dispositifs d’emballage des semiconducteurs de nouvelle génération, Mitsui Mining & Smelting Co., Ltd. (président : Keiji Nishida ; ci-après désignée « Mitsui Kinzoku ») étend l’établissement d’un système destiné à la production de masse en collaboration avec … Substract definition is - subtract. I have heard a few amusing metaphors justifying the mix of esters. Unfortunately, in practice, this is not the case. Over 10-15 years ago there were several progressive doctors in the cash HRT/TRT (hormone replacement therapy/testosterone replacement therapy) space who at some point realized subcutaneous administration of testosterone cypionate or enanthate not only absorbed as effectively as IM (intramuscular injections). We opted for Nebido and followed the treatment guidelines, administering a loading dose at six weeks with subsequent follow up bloods twelve weeks later. The longer the carbon chain, the longer this process takes. In my professional opinion, Gold Standard TRT is daily subcutaneous injections of Testosterone Enanthate or Cypionate and HCG, this is something I discuss in detail in TRT Best Practice. In practice, it appears that the shortest acting ester, Propionate, is the most important determinant in deciding the optimal protocol for relative stability. Keep it simple, keep it safe. It has a half-life of approximately 7-9 days. TRT Ertugrul by PTV's channel, the place to watch all videos, playlists, and live streams by TRT Ertugrul by PTV on Dailymotion
SUBQ TRT daily shots , anyone doing this ? The aim of Testosterone Optimisation Therapy (TOT) is to optimise your androgen levels so that you feel the qualitative and quantitative benefits of having healthy hormonal levels. I make sure to rotate the injection sites and inject subq with a 29 gauge needle. Its half-life is approximately 90 days, with stability being achieved in approximately 450 days. The figure below shows you the exact location of these two injection t… SUBQ TRT daily shots , anyone doing this ? We bring you daily newspaper news coverage 24 hours a day, 7 days a week. Sub q TRT never worked for me either and I too prefer delt injections. When The Men’s Health Clinic opened in January 2016, we looked at the various treatment options available in the UK. The intake of arginine aspartate has been shown to increase anabolic hormones like human growth hormone (hGH) and glucagon. Substrate definition, a substratum. I use 29g 5/8..40mg eod.. pin..and done..takes like 2 sec. Esters are essentially a class of organic compounds that react with water to produce alcohols and organic or inorganic acids. The qualitative effects of TRT are due to stable levels with the correct androgen ratio of the different hormones. 9-10 Longham Business Park How to use substract in a sentence. You cannot have a cookie-cutter approach to TRT. Whilst the majority of our patients are on Testosterone Cypionate as this is the Gold Standard, some of my patients are fortunate enough to have their testosterone prescribed through the NHS, under my guidance and supervision. This is why we carefully titrate the prescribed dose of testosterone and HCG according to effect. I swapped to subq for my self prescribed trt injections a good while back, a few years I would say. Nebido contains the long undecanoic acid ester. They also considered  the benefits of using HCG alongside TRT. My doc has me on 160mg/week split into 2 subq injects, so 80mg Tues night and sat morning. It is still important because it must be taken in context with other proteins in the body, such as Sex Hormone Binding Globulin (SHBG) which binds to testosterone preventing it from becoming bioavailable. Shortening the interval between injections brought about sustained symptoms of supraphysiological markers of excess free testosterone, oestradiol and dihydrotestosterone. Its half-life is approximately 90 days, with stability being achieved in approximately 450 days. Sustanon contains a blend of four esters: The pharmacokinetic properties of Sustanon are not too dissimilar to that of Testosterone Enanthate. For us to understand this, we need to understand both pharmacokinetics, which is what the body does to the testosterone once administered, and pharmacodynamics, which is what the testosterone does in the body. It is recognised that it takes approximately 5 half-lives for this to occur. How would subcutaneous testosterone injection compare with intramuscular injection for TRT? 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