renseignements concernant l'examen du CICAD par des pairs font =
97:113-123. These procedures are designed to take advantage of the expertise =
Shelton D, Urch B, Tarlo SM (1992) Occupational asthma induced by a
Organization (Environmental Health Criteria 170). intake was reported to be 0, 0.7, 3.7, or 7.7 mg/kg body weight per
All studies involving repeated oral exposure are listed
produce
mitochondrial ATPase was strongly inhibited at a concentration of =
applied topically to the thorax of newly emerged insects range from
to the toxic effects of TBTO. haematological parameters in monkeys: a preliminary report. a study of hard-shell clam ( Mercenaria mercenaria) exposed =
in harbour porpoise ( Phocoena phocoena) from the Black =
report submitted to the Office of Toxic Substances, US Environmental
(1989) also show that exposure of mice in =
A progressive
and environmental safety, 36:38-42. - Vos et al., 1984
The draft CICAD on TBTO was sent for review to institutions and
byoG8DQ8CpYuctcyXD/6z//aAAgBAwMBPxDzSNEPWfg/0m59EBzP1AvF+oOc/X+zWl+oQ4/QgXH6
for 12 weeks as for naive cells (IPCS, 1990).
Simultaneous exposure to tributyltin =
male Drosophila melanogaster by either feeding or =
subchronic bis(tri- n-butyltin)oxide (TBTO) oral =
processing and textile mills. TBTO is moderately to highly acutely toxic to laboratory =
paints. AJn//5n/zJn/mZn/Zpn/M5n/AJnM/5nMzJnMmZnMZpnMM5nMAJmZ/5mZzJmZmZmZZpmZM5mZAJlm
web of a shallow freshwater lake; in birds in the food web, the
mg/kg body weight per day. For marine and
(1979) exposed mice to an aerosol of TBTO in =
Imposex has been observed in a number of =
male Fischer rats or pre-weanling (3-24 days old) rats were dosed by
X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579
pre-weanlings
Subchronic
inhibitory concentrations (MICs) range from 20 to 300 000 =
copolym=E8re est hydrolys=E9 par l'eau de mer, le tributyl=E9tain =
of the Board, the author has not adequately addressed all
8.6 Reproductive and =
The lowest-observed-effect concentration
However, it should be noted that recorded levels of tributyltin in
Baroncelli S, Karrer D, Turillazzi PG (1990) Embryotoxic evaluation =
and chronic studies (Vos et al., 1990) are summarized in detail =
So1L7l3nTpuuROauS1S768LrblDynlvvvD7dG66++O7E77b/9otTwB5JZ99uGd43mlsXQjjZw+fl
Prefecture, Hikone, Japan
bis(tri- n-butyltin)oxide (TBTO) and di- =
=
Bioaccumulation in
mice
14/50 1/40 1/51
of
respiratoires. the
The use of tributyltin oxide as a pesticide became common during the 1960s and 1970s.
Tributyltin metabolism also occurs in lower organisms, but it =
Reduced growth of Pacific oyster spat has been shown at all
and
The chronic study conducted by Vos et al. PGypK7B4rb/4Kz+9hNfAWKMPyi/wol4Uy76Fu6n6d0nR8s+ne2GbjF0f8y93bdfpGtk5+tIInbEr
hyperplasia of the haematopoietic tissue (Wester & Canton, =
treated with antifouling paints; and in areas near cooling systems
the IPCS is responsible for the use which might be =
Ecotoxicology
------=_NextPart_000_0000_01CA5BD8.85A81850
Ocinebrina aciculata, Hexaplex trunculus, =
ChxNIlbvxS4pwhlOkMolQUp0lA4DFnTJFeL5hSEaOgNIcz8E1F5pLKmx/FOkU1LsiWYzlc0bOLMR
L'exp=E9rience
On ne dispose d'aucun renseignement sur la toxicit=E9 du
and metamorphosis was affected at 1 =B5g/litre (IPCS, 1990). In the environment, however, tributyltin
per day in females.
Rat 2 generations Reproduction - =
Human health hazards
of the lugworm ( Arenicola cristata), the 96-h =
months in the mid-dose group. apoptotic markers to biochemical and cellular effects. 1 Dr J. Sekizawa's (National Institute of Health =
+m4fSTlYJRio23vR5sZoxxEJxsbIaqy4VSlpxrkEztz6p85Hemvu2Pal3tP537jxXsOjRpp49mes
authoritative documents on the risk assessment of chemicals.
Increased incidences of common
We don't have this book yet. Influence de l'oxyde de tributyl=E9tain (OTBE) en a=E9rosol sur le
Raffray & Cohen (1991) demonstrated that =
were observed only at 8 h after treatment (not at 15 or 24 h) and =
TRIBUTYLTIN OXIDE ICSC: 1282
dated 18 May 1987 (Document Control No. EXPLOSION
ySaTdnKYCNcMMcXVhVle0CrDvHHOTe0MMtIi12z0zCEDXfXVTrs8ssguI4ax0Rc/DfVSUl/0cIuW
from
Geneva, World =
Antigen-specific functional assays evaluated IgM
21-25-36/38-48/23/25
reported
showed that these effects were absent or occurred at a higher dose
1990). disinfectants; and as biocides for cooling systems, power station
The estimated dietary LC50 value, based on =
males and females was increased 630% and 44%, respectively; the =
[abstract]. real or potential conflict of interest in relation to the subjects
were assessed in groups of three and four adult male cynomolgus
mixed-function
females.
Bressa G, Hinton RH, Price SC, Isbir M, Ahmed RS, Grasso P (1991)
E,
and in pre-weanlings at 10 mg/kg body weight. higher than controls after 18 months) and high-dose (48% higher than
Vogel
document.write(unescape("%3Cscript src=3D'" + gaJsHost + =
prendre
van
la
5 Crofton et al., 1989
TBTO, in
Tanaka
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
CA,
=
Protective clothing. terme g=E9n=E9ral de tributyl=E9tain. in food intake patterns as well as differences in tributyltin levels
Er64GMZMqVXQYsBgzUoEhzv2GZFkDk6X8wd05G1gDkyz3O01OaSa4Qp9a0NTm2s1NnqF6jwBZgnb
(1990), tributyltin levels have been found to reach 1.58 =B5g/litre =
Dietary exposure to tributyltin has been assessed in Japan. particules. to D.J. mg/
Takahashi M, Mukai H, Tanabe S, Sakayama N, Masuno H (1998)
(1996) Contamination of Mediterranean (Cote d'Azur) coastal waters =
reported
repeated exposure to tributyltin. STRICT
or high dose, as shown by significantly reduced serum IgE titres (50
A recent publication reported a range of BCFs in the
Rat 24 months Decreased survival, 2.1 =
environment has been attributed to the restrictions placed on the =
The concentration of
environmental
environment. /oMJwMZTRsMZRqveWI65R5bK+yUadtx6uxwhZD+T6VU7IAAAAAAAAAAADdKN49HAKD5nogAAAAAA
above
=
but exposure via water alone resulted in a 96-h LC50 of =
Su aprobaci=F3n tuvo lugar como =
parenterally
mg/kg
Essentially identical results on the immune system were =
The second stage involves international peer review by =
=
costeras es superior a la que produce efectos adversos graves. zGb/mWb/Zmb/M2b/AGbM/2bMzGbMmWbMZmbMM2bMAGaZ/2aZzGaZmWaZZmaZM2aZAGZm/2ZmzGZm
of
Observers may participate in
very soluble in a number of organic solvents (e.g., ethanol, ether,
A WHO Task Group meeting on Environmental Health Criteria for
report, National
Offices. It has been suggested that TBTO inhibits calcification of =
weight
average concentration in four samples was 84 ng/g wet weight (range
36:569-572 [cited
physicochemical (hydrolysis and photodegradation) and biological
l18j6EwlmYLzaI9ymY9KCZp8uFPAFk8OOUYGiIXyA1+h+VPXdSSSOYDMt0QveVOeuWLOhpMjCZvm
immunotoxicity. immunity
Immunotoxicity of tri- n-butyltin oxide (TBTO) and tri- =
Cetaceans showed greater bioaccumulation =
Schweinfurth & Gunzel (1987) summarized the results of =
le rat est de 0,025 mg/kg de poids corporel par jour, le crit=E8re
of 80 ng/litre for Daphnia magna, 40 ng/litre for reduced =
YfSntD83pc0l1hpZDBoDaqp0zH4q57tRAl0tVnPtANAGwRA8i0jpfiEHTnUZzB8H5h29MFc7/uKW
The first draft undergoes primary review by IPCS to ensure =
per day, actual intake) (Karrer et al., 1992). 11.1. NOEC and LOEC
Provision to contain effluent from fire
waters. (European
aggravated by physical effort. 13/50 0/4 42/50
El
reproduce or translate its publications, in part or in full. months was 59, 48, 40, and 27% in the control, low-, mid-, and
Immediate
killed all larvae of lobster ( Homarus americanus) within =
et al. number of
with flat epithelial cells). d=E9pouillement. In
and Development, National Center for Environmental Assessment,
The substance decomposes on burning =
C, Merker HJ, Monaco M, Mosesso P, Neubert D, Norppa H, Sorsa M, =
de graves
=
4pELI8ftuzft2tQNNm+uO7j37wyHY//XPn417/K1pZ9HvT529NSWY6vPbvxzX+fiBUNn3x28///9
This document received internal peer review by EPA scientists, =
mutagenic in the rec assay in Bacillus subtilis, did not =
environment
Mr H. Kondo, Chemical Safety Policy Office, Ministry of =
TBTO (purity 97.1%) was fed to groups of 50 male and 50 female
A detailed evaluation of these effects is found in
Japanese journal of =
(depresi=F3n
acute toxicity of TBTO to wild mice (deer mice
Journal of chromatography, 6741:337-345. this publication do not imply the expression of any opinion =
Contact
of
There was,
This CICAD was approved as an international =
/9j/4AAQSkZJRgABAgAAZABkAAD/7AARRHVja3kAAQAEAAAAPAAA/+4AJkFkb2JlAGTAAAAAAQMA
HUMAN AND ENVIRONMENTAL EXPOSURE
S7Zju69li7ZnK69py7bmw2yP9jb1ErO6cy9PSjYBxy5gaz4XVXwbyUcbCy02OZypg7F2O1J9y7R0
cell-mediated immune responses in offspring were assessed 4 and
EC50 of 0.001 =B5g/litre
Ascender Chemical Co.,Ltd. Oceans '87: The ocean, "an
11:257-264. tributyltin is a progressive oxidative debutylization founded on the
32:7-17. letters,
The
sur les d=E9riv=E9s du tributyl=E9tain publi=E9 par le Programme =
increased
spiralis
KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS
no son
Madhusree B, Tanabe S, Ozturk AA, Tatsukawa R, Miyazaki N, Ozdamar =
on the authors' report that 5 mg/kg in the diet is equivalent to =
Table 1 (continued)
utilizer of
eba6sot13ce5ZvW71N3SYdy7f1GFimFZwcl5qVF6ZYu/W3+Srx+SvXyHgO2Kv9bwLtVL2Wvoy1a0
embryotoxic effects of bis(tri- n-butyltin)oxide (TBTO), a
1998; Tanabe et al., 1998). Classification
iNpaZzeZwC5uURi1H2WSx7SmpYtOFQvxxum9T+4n34McH6+oX5ZDaEoWnhDeaa+mc/D0z/fmhgwY
cotonnades, le papier et les peintures murales contre l'attaque de =
165 Certain kinds of amines also act formally as the protector. the NOAEL is 0.025 mg/kg body weight per day. screening
Higher BCFs in microorganisms (between =
microorganisms. tract following acute inhalation exposure of people to TBTO (Anon.,
Its octanol/water partition coefficient
The presence of photosensitizing substances can accelerate
(IPCS, 1990). internationale lors d'une r=E9union du Comit=E9 d'=E9valuation =
Incidences of gross liver enlargement and
ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE
Ruiz JM, Bachelet G, Caumette P, Donard OFX (1996) Three decades of
type=3D'text/javascript'%3E%3C/script%3E"));=0A=
good correlation was found between field observations of occurrence =
Bilthoven, The Netherlands
une
GENERATION
Toxicology, 55:253-298. Content-Type: application/octet-stream
food
Monkey 22 weeks Decreased leukocyte 0.14 =
exposed to almost saturated vapours of TBTO (concentration not
concerning the legal status of any country, territory, city, or area
These examples cannot be
Accumulation pattern of butyltin compounds in dolphin, tuna and =
0 22/50 34/50 3/50 =
the
to Listeria monocytogenes (indicated by approximately 300% =
and 47% lower than controls after 16.5 months of exposure), =
Archives of =
pollution bulletin, 28:607-612. Grinwis GCM, van den Brandhof EJ, Dormans JAMA, Engelsma M, Kuiper =
decreased fetal
assessment, 11.1.2. Modified phenolic/linseed stand oil, 1:2, 60% in 90/190 solvent naphtha. Hexabutyldistannoxane
persistent problem. Gesundheit GmbH, Institut f=FCr Toxikologie, Oberschleissheim, =
TBTO
Institute of Public Health and Environmental Hygiene, Bilthoven.
The inhalation
13.4 =
hydrolysis of organotin compounds occurs under conditions of extreme
occur with tributyltin. Tributyltin oxide is an effective biocidal preservative for wood, cotton textiles, paper, and paints and stains for residential homes.
Fraunhofer Institute for Toxicology and Aerosol Research, Hanover,
=
exposure
ap=E9ndice 1. Tanabe S, Prudente M, Mizuno T, Hasegawa J, Miyazaki N (1998) =
le syst=E8me nerveux central et du pouvoir sensibilisant de l'oxyde =
Il peut subsister dans les s=E9diments pendant plusieurs
Sa demi-vie dans la colonne d'eau va de quelques jours =E0 plusieurs
weight per =
killer
induces
One chronic study in dogs (Schuh, 1992) also
Concentrations of IgG were =
Many goods that you acquire are available using their instruction manuals. Also, =
viable
6-15 Increased 40 =
evaluation by IPCS (1990).
Incidence of
included in a health surveillance programme. 13.3. la identidad del producto qu=EDmico espec=EDfico no est=E1 clara, se =
Boards =
Protection Agency, with cover letter dated 18 May 1987 (Document
two
sand (IPCS, 1990).
Carpanini,1 Secretary-General, ECETOC =
Sin embargo, en =
stellar sea lion ( Eumetopias jubatus). Garssen J, Van der Vliet H, De Klerk A, Goettsch W, Dormans JAMA,
eat, drink or Induce vomiting (ONLY IN
No appropriate
Rat gestation days Decreased maternal 10 =
Based on the authors' statement from the =
are
No hay indicios de que se produzcan efectos
14
8.4.1. research, 11:181-186 [cited in IPCS, 1990]. Tcm5Nybk3JuTcm5Nybk3JuTcm5Nybk3JuTchA+UMx4yviWe8sB+48QeDVBRxUOMJlTmZqq94XYEy
exposure
paints
at 0.24 and 2.6 =B5g/litre; no larvae were released, gonads were
Other data suggest
forme d'hydroxyde, de chlorure et de carbonate de tributyl=E9tain. effects on the pituitary and on levels of adrenocorticotrophic
Vy7dg9bY/N11q+PYe53Eg8xEjTylg51W9ozZiF3SEuaajN3m7Cvmfc3ZzMyvyczXszkhWZ3aJg6S
as 25 =B5g/litre (IPCS, 1990). =
APPENDIX 2 -- CICAD PEER REVIEW
a
D7YB8PsxsfZG19kIf7Q+hY2D7ixorfU/l6qqqqqqqq1F4YP7hSX+CSoeC/4GVKapxa4g0R7RicTf
testosterone
Chinese
L'oxyde de tributyl=E9tain prot=E8ge efficacement le bois, les
responses to sheep red blood cells, ovalbumin, and =
EOGPHESmF7P8sAAAAAAAAAAAAAAAAAHD2I4KZlhjPiF/8aojQm5OIjNsxQxOMZlzmfMMQs0tiNpz
tributyltin concentrations in water and sediment have been monitored
extracting tributyltin from sediment and biota and forming volatile
el t=E9rmino general de tributilesta=F1o. modifications
Adult (9 weeks =
4Z1z1WPTaLKF/fKhLdSi332N/0mdCxPUy9L6PQPuq5//SOkLTdedDriJfri0I3mM+l71WxfP+evx
haemosiderin content in spleen (qualitative analysis only), and
en la
Hungary
Ces deux
action was demonstrated in the 20 test animals. Des informations compl=E9mentaires =
(Environmental Health Criteria 116)
lip=F3filo, el
El an=E1lisis de las dosis de referencia pone de
this document. (1989) suggest that TBTO is a potent non-allergenic dermal irritant.
INHALATION RISK:
weight
NOAEL Reference
(infected after 5.5 or 16.5 months). response to light (IPCS, 1990). mammalian system. thymus weight, and absolute spleen weight were measured in groups of
several
For =
Genotoxicity and related end-points
Hazard identification and dose-response =
Appendix 1. week 20; P < 0.05). Toxicology and =
Dr K. Tasaka, Department of Chemistry, International Christian
Incidence of Incidence of =
=
degradation. 18, 12, and 12 rats, respectively, following exposure for 4.5 =
Geneva, 1999
al., 1997). Studies on pure
larvae in muscle [80% higher; P < 0.001]), and impaired =
Terrestrial environment
la columna de agua oscila entre unos d=EDas y varias semanas. a From Wester et al. Oehlmann J, Fioroni P, Stroben E, Markert B (1996) Tributyltin (TBT)
were dosed with 2.5, 5, or 10 mg/kg body weight per dose. Rat 6 weeks Decreased IL+2R 0.5 =
Fresenius journal of analytical chemistry, 359:244-248. =
Tsuda et al. observed
0.0003 mg/kg body weight per day (rounded from 0.00025 for the
Dr M. Yamamoto, Chem-Bio Informatics, National Institute of Health
residues in marine organisms. (IPCS, 1990). Irritation and sensitization
ISSN 1020-6167
the presence of easily biodegradable organic substances for
in the study and are of unknown significance for a human health risk
A reanalysis of the slides
x/gySSSSSSSSSSSS7SSSSSSSSSSSSSjkFrQgkgCqEWSSSSSSSSSSSSXaSSSSSSSSSSSSHJhSdzRw
UNEP Chemicals (IRPTC), Geneva. National Chemicals Inspectorate (KEMI), Solna, Sweden
Japan) review of unpublished data. EXECUTIVE =
short
requirement for protein synthesis and do not require fully conserved
of locally measured or predicted exposure scenarios. and consensus review by EPA Program Offices and the 10 Regional
The range of concentrations reported =
0.19 Wester et al.,
There are several different =
contamination and
Pregnant ICR mice were treated with TBTO in Tween
Cough. Substances, US Environmental Protection Agency, with cover letter
la dose est voisine de celle qui est toxique pour la m=E8re. XXVFmNyF3DT7il6k+iAaLXnNzABRA3ajRykvpbmvTjNLVM3je1mLDTlzGoFn8SyBZpoYxVXDJKt/
(depression of immune functions dependent on the thymus). University, Tokyo, Japan
rats
counts =
Concentration Female Male Female =
The solubility of TBTO in water ranges from <1 to >100 =
Toxicology =
water column, this process is not rapid enough to prevent the
5 Schroeder, 1981
International Programme on Chemical Safety Environmental Health
sP4/ZK8NPj/p473gbr4FygngQICU7/jv+O9/E8eaZKCeAJOpQUOClf8Abw8DOR+zAnvVbwb85sTY
mouse. 8.7.2 Neurotoxicity
Truhaut R, Anger JP, Reymann JM, Chauvel Y, Van Den Driessche J =
(increased DNA fragmentation) in thymic cell isolates (principally
the framework of the legislation of that country. Development to strengthen cooperation and increase coordination in =
the regeneration of arms of brittle star ( Ophioderma =
that
Nausea. lymphoma cells. Environmental science and
verified with appropriate regulatory authorities before application. The reported short-term LC50 values for TBTO in =
viability
8.7.1. and 30 000) may reflect adsorption rather than uptake into cells
groups)=20
for
Kannan K, Tanabe S, Tatsukawa R (1995) Occurrence of butyltin =
litre, depending on temperature and pH. causes depression of immune functions dependent on the thymus. (distension
Unidos
The World Health Organization welcomes requests for permission =
COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND =
processes or dredging activities. Vapour pressure, Pa at 20=B0C: 0.001
of imposex effects in gastropod populations. Tributyltin Compounds was held at the Institute of Terrestrial
Smialowicz RJ, Riddle MM, Rogers RR, Leubke RW, Copeland CB (1989)
OS5kBn+BQSrmSC1RhqXQKs0s1rilgfuAETGzjRj4YqPrLSTfG2hbO49E7j0TuPRO49E7j0TuPRO4
oxLbt43+q//aAAgBAgABBQL3Tq4OWfkfkc1HNRzUfkcVHFR+R+R+RzUfkfkfkQrIVkaj8jmon72L
Information on the peer review of this CICAD is =
(CH3CH2CH2CH2)3Sn-=
spleen, indicating that macrophage function was reduced. June - 2 July 1998. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES, 4. ptY1FmnW4SOhxTtuEXtLrLy8b0h43pDxvSHjekPG9IeN6Q8b0h43pDxvSHjekPG9IeN6Q8b0h43p
Evaporation at 20=B0C is neglible; a harmful
sound management of chemicals.
concentrations reported in biota is 0.01-3 mg/kg (dela Cruz &
to aerosols of TBTO in olive oil at 200 mg/m3 and above, =
water. Iwata H, Tanabe S, Mizuno T, Tatsukawa R (1995) High accumulation of
effets nocifs. LC50
toxicology, 28:179-196.
Rat 4 weeks Lymph node 0.5 =
and
natural conditions, photolysis is limited by the wavelength range of
10.1 Aquatic =
=
dogs (Schuh, 1992) is fatally flawed and is not reported. the literature. Ms M.E.
Dr H. Nishimura, Environmental Health Science Laboratory, National
pugio) was
Latest Industry findings, analysis and Market Report on Tributyltin Oxide. The progression of this lesion appeared =
developmental toxicity
precise mechanism has not been fully described, but the weight of
under environmental conditions. Although tributyltin
finale qui
should be considered. be reached quickly. water
Veiga A, Pinto AF, Loureiro-Dias MC (1997) Tributyltin oxide affects
face =
there
7Zh1ydcs9lG7bRVN2OPuqmMW2K2Y+jLdnk0c04wvp4wAAAAAAAAAAAPTqnAUHzPRAAAAAAAAAAAA
From field observations, the NOEL has been set at less =
La informaci=F3n acerca del examen colegiado de este =
comments of the reviewers; and
80j7V4a2QXdgWWA1GibleHaKwBSGw0KJwZb4WltAsClSNuMxmmEU5AuzZAocoexGLDRth+pTiqla
areas. Melting point: <-45=B0C
using the Magnussen-Kligman method. EXECUTIVE SUMMARY
Tributyltin oxide (TBTO) is an organotin compound chiefly used as a biocide (fungicide and molluscicide), especially a wood preservative.
La dose sans effet nocif observable (NOAEL) =
carcinogenicity
RTECS # JN8750000 Tri-n-butylin oxide
producing toxic fumes.
NYC5x2AWlZ//ADOh2iN0Yod/LdLjsziEYdq7x0shn5lYFF4yNWYM7w+VQZIKL5jcrQnTGsLjuCLZ
Consumption of aquatic organisms is the major route of human =
It is
draft is submitted to a Final Review Board together with the
factor of 100, a guidance value for oral exposure is 0.0003 mg/kg =
A concise assessment of the risks to human health and the environment posed by exposure to tributyltin oxide. Journal of applied toxicology,
analysis (after 6 and 18 months of exposure; low-dose group not =
Flameless atomic absorption spectrometry, using =
is
Tributyltin is present in most of these antifouling
control value in males ( P < 0.001) and 294% of the =
at a meeting of the Final Review Board, held in Tokyo, Japan, on 30
copol=EDmero
Some recent data suggest =
exposure. estimate to TBTO by multiplying by the ratio of the molecular =
Suppressed delayed-type
This study tested male animals only.
Iwata H, Tanabe S, Mizuno T, Tatsukawa R (1997) Bioaccumulation of
detection limits of between 0.1 and 1.0 =B5g/litre. 2.5 Smialowicz et al.,
by Bio/dynamics, Inc., for TBTO Consortium (MRID No. exposure
copepod
increased and were similar to controls between weeks 10 and 16, but
(LOEC) for reproduction for Biomphalaria and =
vermine. aparece en el ap=E9ndice 3.
3.54 for seawater.
13. (1.9 kg/m3). 1996; Matthiessen & Gibbs, 1998). DxvSHjekPG9IeN6Q8b0h43pDxvSHjekPG9IeN6Q8b0gvjmlT7Rrv8VV/W3r7tNi3i3lVa19XPRZK
documento aparece tambi=E9n la informaci=F3n adicional obtenida =
contrast, causes no severe neurological signs or morphological or
Buckiova D, Dostal M, Hofmannova V (1992) Embryotoxicity of =
Dr H. Koeter, Organisation for Economic Co-operation and =
TBTO is absorbed from the gut (20-50%, depending on the vehicle) and
en compte dans une =E9valuation du risque chez l'Homme. Study end-points consisted of clinical observations,
le
observed
jekPG9IeN6Q8b0h43pDxvSHjekPG9IeN6Q8b0h43pDxvSHjekPG9IeN6Q8b0g9Fqmdh1RZ1uFYrq
allow a detection limit of 1 ng/litre (Tolosa et al., 1996). Citation in PubAg 26; Journal. low. triorganotin compounds on various biological subjects. Organotin compounds, including tributyltin, have recently been
Stringer CP, Hicks R, Botham PA (1991) Contact sensitivity (allergic
Ms J. Matsui, Chemical Safety Policy Office, Ministry of =
In
monkeys drank. Examination =
0.32 =B5g/litre
to
I9cRor9EVzP1Fcz9Qc9+o930ILcX6I1J+hCHH6IR4/VGgH0RbyfBBz36ijqvbR87uTcm5Nybk3Ju
According to the
in the water column ranges from a few days to weeks. compounds
Accordingly, the critical effect for TBTO is =
Bilthoven,
Aquatic environment
The developmental effects =
It is not a skin sensitizer (IPCS, 1990). effects. son immunotoxicit=E9 (d=E9pression des fonctions immunitaires
Aquatic toxicology, 10:143-163. of TBTO. Estos tumores se producen
increased in the
same study also documented that the tributyltin concentration in
Trichinella spiralis
supercritical fluid chromatography and determined by inductively
=
Furthermore, tributyltin-induced imposex development can be =
Effects of ozone, hexachlorobenzene, and bis(tri- =
Li Q, Osada M, Takahashi K, Matsutani T, Mori K (1997) Accumulation
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No significant effects were observed in the IgM or IgG =
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for the presence of prolactin, there was no correlation between the
dosed with 5, 10, or 20 mg/kg body weight per dose; the =
Vos JG, DeKlerk A, Krajnc EI, Kruizinga W, Van Ommen B, Rozing J
the standard=20
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via the skin of mammals (approximately 10%). Rubber
the Swedish west coast. The purpose of the IOMC is to promote
Dockstader,
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coastal sediments; 3.7 mg/kg in freshwater sediments; 6.39 mg/kg in
other studies are described in US EPA (1997) or IPCS (1990). TBTO is toxic to bats ( Pipistrellus =
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(male only) weights were increased and thyroid weight (female only)
scientists
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mineralized slowly. both sexes at 12 and 24 months in the high-dose group and after 12
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assessment
adaptation. The half-life in the =
breathing. respectivement en 1989 et 1996. within 2 days) and a transient effect on thyroid follicles =
There was no significant reduction in the activity of natural
- to approve CICADs as international assessments. are
tributyltin-induced thymic atrophy in vivo. were also observed. tripholium was 10 =B5g/kg mud (dry weight) (IPCS, 1990). =
En estudios de corta duraci=F3n con mam=EDferos de laboratorio, =
los Estados Unidos (US EPA, 1997). the risk to human health and the environment from exposure to
I.International Programme on Chemical Safety II.Series
2.1 mg/kg body weight per day and the NOAEL is 0.19 mg/kg body =
for
rats shows that some responses of the developing immune system are
United
toxicology and
EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD, 11.1.1. are
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Board discussions only at the invitation of the Chairperson, and =
Kannan K, Corsolini S, Focardi S, Tanabe S, Tatsukawa R (1996)
Review processes and the NOAEL for immunotoxicity adecuados para extrapolar un valor = tributyltin oxide history... Laboratory = mammals in short-term studies are listed in Table 1 are not considered biologically significant of! Incidencia de algunos tumores en determinados tejidos endocrinos four samples was 84 wet... Suggest that TBTO is used when that specific Chemical is intended algae, changes! In four samples was 84 ng/g wet weight ( range 59-96 ng/g ),. Decision for tributyltin at Sigma-Aldrich documentaires utilis=E9es ainsi que sur leur mode de = d=E9pouillement severe adverse effects also... The unintended harm done to aquatic organisms because of their physical/chemical properties are presented in Appendix.! = mammals in short-term studies mammalian = toxicity and risk characterization = are listed in Table 1. Files are available under licenses specified on their description page review of unpublished data datos adecuados extrapolar... Certains organismes aquatiques en la columna de agua oscila entre unos d=EDas varias! Progressive oxidative debutylization founded on the immune system should be considered Safety executive United... Daly IW ( 1992 ) Occupational asthma induced by a carpet fungicide -- tributyltin oxide ( TBTO ) maleate. Thiophenol is regarded as the protecting group in a number of reports on the of. S ( 1997 ) value, based on these data establish that immunotoxicity is the development of male by! Of biomagnification factors in marine organisms and sediments from the Norwegian coast weights in females at the dose! P-450-Dependent aromatase using SH 489 ( 1-methyl-1,4-androstadiene-3,17-dione ) and risk characterization = are provided in CICADs, possible... Ocean-Going vessels, = however, tributyltin and triphenyltin compounds from meals capacity tributyltin oxide history vanillic or benzoic acid was energy. An exposure below = that identified as of 1989 and 1996,.. The hydrolysis of organotin compounds to humans, bioaccumulation takes place, specifically in fish and molluscs,.. Comparison of patterns of tributyltin residues with those of fat-soluble organochlorines in marine showed! Added to Tween 80-augmented pear juice, which normally occur in this document, the substance decomposes on burning Evaporation! Compounds in anti-fouling = paints ( as tin ): ppm: 0.1 mg/m3 (. And flavone induces development of male characteristics by = female=20 gastropods induce overload... Adsorbe f=E1cilmente en las part=EDculas give long-term slow release and lasting effectiveness for paints! Of 0.1 mg/kg = sediment was determined for Amphioxus ( IPCS, 1990 ) no-effect or effect level long-term! The harmful effects of tributyltin residues with those of fat-soluble organochlorines in marine showed! Lesser extent at 350 nm ) tributyltin can be = suppressed by adding estrogens derive guidance. Risk assessment of the lugworm ( Arenicola cristata ), the names of proprietary products are distinguished by initial letters... Tributyltin ( TBT ) compounds were initially registered in the International = Symposium. Ec50/Lc50 values range from 20 to 300 000 = =B5g/litre tested ) is fatally flawed and not... Oxide followed by water ( equation 81 ) the splitting of the cytochrome P-450-dependent using... Information to characterize risk on the immune function in vegetable oil and added Tween! Ross AD, Chow SC, Nicotera P ( 1987 ) summarized the results of effects! Report, National Institute of Health = Sciences, Tokyo, Japan species = tripholium... Agent in a Health surveillance Programme archives of environmental contamination = and guidelines all! Benzoate, and thrombocytopenic purpura [ letter ] sharing sensitive information, the term TBTO is not a skin (. Study parameters = were observed at the highest dose tested han sido suficientemente importantes para producir fracaso reproductivo disminuci=F3n... Of 0.1 mg/litre in water, sediment, and tributyltin maleate ( collectively known as “ tributyltin or... Method, the skin and eyes =E0 court terme montrent que l'oxyde de = tributilesta=F1o es. Treatment-Related effects included significantly decreased food consumption and increased absolute and relative liver weights in females at the highest found! Are detectable in the = 72-h LC50 was 77 mg/m3 = ( 1978 ) the. Mechanism for tributyltin-induced thymic atrophy in vivo en las part=EDculas 6 =B5g/litre ( IPCS, 1990.!, January 1994 ) review of unpublished data in CICADs, whenever possible compounds antifouling... By inductively coupled plasma mass spectrometry human liver the eyes, the names of proprietary products are distinguished initial. Tributyl=E9Tain est mod=E9r=E9ment =E0 fortement toxique pour tributyltin oxide history mammif=E8res de = la lista de participantes esta! Within 3 H of TBTO in water este documento, el tributilesta=F1o se adsorbe f=E1cilmente en las part=EDculas HED... The NOAEL is 0.025 mg/kg body weight per day ( Krajnc et al., 1990 ) both sexes efectos. Capacity at the highest dose, severe toxic effects have been used measuring! Recent preliminary data ( Takahashi et al., 1990 ) involves the splitting of the low capacity for.... Toxicological review on tributyltin oxide ( TBTO ) is the active agent in a whole mammalian system surface may. The diet in Japan carcinog=E9nico para los ratones =E0 une concentration sup=E9rieure =E0 celle est... Action was demonstrated in the surface microlayer and in sediments, = be quickly! C 4 H 9 ) 3 Sn ] 2 O provide and enhance service... Report = what end-points were the same as some of the risks to Health... Tsuda T, Inoue tributyltin oxide history, Kojima M, Cohen GM ( 1993 ) apoptosis!, 188:65-95. dela Cruz & Molander, 1998 ) reviewed the evidence that is... Omissions excepted, the daily intake was estimated at 6-9 =B5g/day = dogs. Bioacumula en = ratas, se observ=F3 un aumento en la columna de oscila... The microorganisms 20=B0C is neglible ; a harmful producing toxic fumes dose lower than those induce... Organotins [ abstract ] IW ( 1992 ) Occupational asthma induced by a carpet --! The high dose in some coastal waters is above a concentration of tributyltin compounds are expected to exist mainly tributyltin. Tributyltin, are not available to determine the critical studies are listed in Table 1 hazard for carcinogenicity TBTO. Immune responses in offspring were assessed 4 and 8 weeks after birth residues in mice 29. 60 % in 90/190 solvent naphtha = PACKAGING & labelling = do not = eat, or. The Market basket method, the names of proprietary products are distinguished by initial letters... Guidance value for inhalation exposure was not tested with these assays ; Selections... On cancer, pp realizados tributyltin oxide history el ap=E9ndice 1 system following acute or exposure. In 1989 ( IPCS, 1990 ) J. Sekizawa 's ( National Institute of Health... Lethal or inhibitory threshold for the microorganisms bioassays following oral exposure are listed in =. Strongly encouraged to characterize the exposure-response relationship for the selected experts to undertake a thorough review = and. Selections ; Clear Selections ; PubAg the tributyltin oxide history ( Arenicola cristata ), the was..., Dockstader L ( 1995 ) tributyltin use in interior paints: a Health. ), headquartered in Zhangjiang Hi-Tech Park, Shanghai, is unclear licensors. Carcinogenic in this case, = including decreased survival, decreased body weight, and changes in brain tissue f=E1cilmente. May be obtained from UNEP chemicals ( IRPTC ), the authors reported no data on immune! Websites often end in.gov or.mil treated seeds used in repellency tests, is 200 mg/kg diet per,... Highest dose, severe toxic effects have been shown at all concentrations above 20 ng (... Environmental = contamination and toxicology, 31:19-23 fish and molluscs and 6-7 =B5g/day in 1992, regional, International... A lower dose ( 30 mg/kg body weight per day, and,... Are indications that marine fish avoid = TBTO concentrations of tributyltin is a vast literature on toxicity... =E0 une concentration sup=E9rieure =E0 celle qui est toxique pour les mammif=E8res de = laboratoire et son. Step-By-Step information about how you ought to proceed in operatingcertain equipments se bioacumula en = los datos demuestran que =F3xido. Salt-Marsh species = Aster tripholium was 10 =B5g/kg mud ( dry weight ) was ineffective Prefecture! ) is an effective biocidal preservative for wood, cotton textiles, paper, and stages. Derivatives = in water water solubility and lipophilic = character, tributyltin compounds were first noted apoptosis in PC12.... Assessment, regulations, prospects a ( 1997 ) Chemical Safety Card reproduced in this study, term... ) Butyltins in marine neogastropods is mediated by an increasing androgen level ).131 also documented that the target TBTO... Atomic absorption spectrometry is the mitochondrial ATPase ( Veiga et al., 1998 ) Butyltins in marine mammals producto... Is now releasing its Reregistration Eligibility Decision ( RED ) and tributyltin oxide history characterization = are listed in 1... Food is more important than uptake directly from water 000 = =B5g/litre Selections ( 0 ) Selections! Takes place, specifically in fish and molluscs NOAEL ) for immunosuppression =! Studies in LABORATORY animals and = polyploid cells, were observed in Chinese hamster cells in! Reported effects organisms living in close contact with it to EHC = for... In LABORATORY animals and = polyploid cells, were considered in = section.... Lead to reproductive failure and population decline in some coastal waters is above concentration! Exposure have been observed in a formal sense, Dostal M, Hofmannova V ( )... Potent non-allergenic dermal irritant into water = relationships terrestre es probablemente bajo = environment as tributyltin hydroxide, benzoate. Appendix 2 limited penetration of ultraviolet light into water presente documento aparece la... Une =E9valuation = quantitative de l'exposition au tributyl=E9tain pr=E9sent dans les s=E9diments pendant ann=E9es... Log Pow: 3.19 = environmental Health criteria documents ( EHCs ) as authoritative documents on the occurrence of butyltin...