Topical flea and tick control kills for 30 days. Bravecto tablets were administered to intact, reproductively- sound male and female Beagles at a dose of up to 168 mg/kg (equivalent to 3X the maximum treatment dose) on three to four occasions at 8-week intervals. In the field study, two dogs treated with Bravecto with no prior history of seizures each experienced a seizure. Adobe InDesign CC 2015 (Macintosh) Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. Bravecto (Fluralaner) is a Topical Solution for Dogs that kills fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks. The dogs in the control group (0X) were administered mineral oil. The dogs in the control group (0×) were administered saline orally. CPN:1208298.2 Do not eat, drink or smoke while handling the product. 2017-07-12T12:56:09-04:00 Each tube is packaged individually in a pouch. Dosage and Administration: Bravecto should be administered topically as a single dose every 12 weeks according to the Dosage Schedulebelow to provide a minimum dose of 18.2 mg/lb (40 mg/kg) body weight. For topical use only. Every effort has been made to ensure the accuracy of the Bravecto (fluralaner topical solution) for Dogs information published above. Fluralaner is an inhibitor of the arthropod nervous system. 17 January 2017 . Margin of Safety Study: In a margin of safety study, Bravecto was administered topically to 8- to 9-week-old-puppies at 1, 3, and 5X the maximum labeled dose of 56 mg/kg at three, 8-week intervals (8 dogs per group). As of November 1, 2020 there have been 1380 reports of human adverse reactions reported to the EMA. During veterinary examination at Week 7, two pups from the control group had inguinal testicles, and two and four pups from the treated group had inguinal and cryptorchid testicles, respectively. That's easy and convenient treating, fewer chances to forget and a better experience for you and your pet, all taken care of with … Keep this and all drugs out of the reach of children. %PDF-1.3 %���� Each milliliter contains 280 mg of fluralaner. BRAVECTO® Vir Miniatuur Honde (2 - 4,5 kg) Vir Klein Honde (> 4,5 - 10 kg) Vir Medium Honde (> 10 - 20 kg) Vir Groot Honde (> 20 - 40 kg) Vir Ekstra Groot Honde (> 40 - 56 kg) Reg. DATE OF PUBLICATION OF THIS PACKAGE INSERT. Bathing or water immersion 3 days after administration will not reduce the effectiveness of Bravecto against fleas and Ixodes ricinus ticks (see Effectiveness). In cats, Bravecto® Spot On provides 3 months of protection against fleas and ticks. In a well-controlled laboratory studies, Bravecto killed fleas and reduced the numbers of live fleas on dogs by >99% and 100% within 24 and 48 hours, respectively, post-infestation for 12 weeks. Dogs with signs of flea allergy dermatitis showed improvement in erythema, alopecia, papules, scales, crusts, and excoriation as a direct result of eliminating flea infestations. H��W[sۺ~׌���I �y�L'm�i{z��y�2��$ּ�������%��X�i�`��o{�8����8{�����V��n��E_f�I�xf�e2`�9��lVN��5we�7I�T�a]��Ӥ`m]�]^W�)[� ��W�t�o-����GZhH2�8;-\f������2@6������5��[lT�+�(��]V/YŠ�M���U{R�j�*i�rN%XGpOC߫6m��E���l��=��I�f]�P*���/�pPl��Oy��F�Wyٗ,��+�S�]'f���X�P�����]�ٖ=�|���ʼ(�"� l�}�gh-f�@ZW]�W-�$~쮩0��wl�/�,e��C1���{�ҵ*�s��T���BĂ�|j{��o�-y��Y�����7kUm��t~c�|�oc�TݚvlO_o�����G�{]��&��nf�m����i~��� 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 In cats, Bravecto® Spot On provides 3 months of protection against fleas and ticks. PDF/X-1:2001 1,2 The Bravecto® Spot-On in dogs provides 4 months of tick protection and 6 months of flea protection. If your dog has a history of seizures or you have a lactating dog, you should talk with your vet about the proper medication that kills ticks effectively. uuid:c31aeb85-d228-d84e-94db-e35d08d0e1f9 Indications: Bravecto kills adult fleas and is indicated for the treatment and prevention of flea Adobe PDF Library 15.0 References: 1. Free Shipping over $39. Step 2: The dog should be standing or lying with its back horizontal during application. BRAVECTO kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) for 12 weeks. Bravecto Plus may be administered year-round without interruption or at a … False Bravecto may be administered every 8 weeks in case of potential exposure to Amblyomma americanum ticks (see Effectiveness). Made in Japan. Free Shipping over $39. The Bravecto topical solution for dogs and cats is included in the report mentioned in this story. There are no known contraindications for the use of the product. The tube is open and ready for application when a breaking of the seal is felt. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. BRAVECTO ® (fluralaner) Topical Solution >88-123 lb 1 Tube. Adobe InDesign CC 2015 (Macintosh) One treated animal experienced loose feces with blood three hours after administration. FOR ANIMAL USE ONLY. Additional information can be found at www.bravecto.com. The product is highly flammable. Available in three strengths with an easy to use applicator. Updated: 2020-11-27. CONTENTS: 1 TUBE CONTAINING 1400 MGFLURALANER . No undescended testicles were observed at the time of necropsy (days 50 to 71). Bravecto is not effective against lone star ticks beyond 8 weeks of dosing. If your order is more than $39, it ships FREE anywhere in New Zealand, including rural addresses. BRAVECTO ® SPOT-ON Reg. 1 0 obj <>]/Pages 3 0 R/Type/Catalog/ViewerPreferences<>>> endobj 2 0 obj <>stream The Human reports represent 8.73% of cases for all species. RotisSansSerif-LightItalic For topical use only. For topical use only. or greater. One adult treated dog suffered a seizure during the course of the study (46 days after the third treatment). Step 1: Immediately before use, open the pouch and remove the tube. BRAVECTO is also indicated for the treatment and control of tick infestations with Dermacentor variabilis (American dog tick) and Ixodes scapularis (black-legged tick) for 8 weeks. Abnormal salivation was observed on 17 occasions: in six treated dogs (11 occasions) after dosing and four control dogs (6 occasions). Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. Five of the six treated dogs experienced salivation immediately after administration. xmp.did:A6150B3F132068118083C6B6E3A95A4D Bravecto Topical Solution for Dogs: The most common adverse reactions recorded in clinical trials were vomiting, hair loss, diarrhea, lethargy, decreased appetite, and moist dermatitis/rash. BRAVECTO (Fluralaner Topical Solution) is available in five strengths for use in dogs (112.5 mg, 250 mg, 500 mg, 1000 mg, and 1400 mg fluralaner per tube). Oral Safety Study: In a safety study, one dose of Bravecto topical solution was administered orally to 8- to 10-month-old-puppies at 1X the maximum labeled dose of 56 mg/kg. Bravecto is available in five strengths for use in dogs (112.5, 250, 500, 1000, and 1400 mg fluralaner per tube). Bravecto has been approved for use in breeding, pregnant, and lactating female dogs. In a European laboratory study, Bravecto demonstrated ≥98.2% effectiveness against fleas and Ixodes ricinus ticks after multiple water immersion or shampooing occasions, the first occurring 3 days after application, for 12 weeks. One dog had two seizures a day apart about 18 days after its first dose. Bravecto® provides 12 weeks of protection against fleas and ticks in dogs with the tasty Chew. Buy Bravecto - Vet Only Products for your Dog - A great place to buy pet food and pet supplies - Pet.co.nz. Inactive ingredients: dimethylacetamide, glycofurol, diethyltoluamide, acetone. endstream endobj 3 0 obj <> endobj 6 0 obj <>/Font<>/ProcSet[/PDF/Text]/Properties<>>>/TrimBox[0.0 0.0 612.0 792.0]/Type/Page>> endobj 7 0 obj <>stream However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert. application/pdf Adverse events reported to date are classified as rare. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Bravecto® Spot-On is well tolerated in MDR1 dogs. Product may be supplied in 1 or 2 tubes per carton. (fluralaner topical solution) for Dogs BRIEF SUMMARY (For full Prescribing Information, see package insert) Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Distributed by: Intervet, Inc., (d/b/a Merck Animal Health), Madison, NJ 07940. Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Stop a flea infestation with the mighty killing ... Plus, it works non-stop for 30 days on dogs and cats. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 1,2 It has been tested and found safe in puppies at least 8 to 9 weeks of age at 5x the clinical dose. Bravecto is a prescription strength topical just for cats. Treatment with Bravecto may begin at any time of the year and can continue year round without interruption. Percentage of Dogs with Adverse Reactions in the Field Study, Bravecto Group: Percentage of Dogs with the AR During the 105-Day Study, Active Control Group: Percentage of Dogs with the AR During the 84-Day Study. In a well-controlled U.S. field study, which included a total of 165 households and 321 treated dogs (221 with fluralaner and 100 with a topical active control), there were no serious adverse reactions. If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into the mouth. One dog with a history of seizures had a seizure the day after the second dose of the active control. UniversLTStd-Light The cap should be rotated clockwise or counter clockwise one full turn. No. The pouch should only be opened immediately prior to use. In a European field study in cats, there were three reports of facial dermatitis in humans after close contact with the application site which occurred within 4 days of application. If contact with eyes occurs, then flush eyes slowly and gentl… The safety of BRAVECTO PLUS has not been established in breeding, pregnant and lactating cats. Kills fleas and ticks For dogs and puppies 6 months of age and older Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Wenn die Tablette vom Hund nicht freiwillig aufgenommen wird, kann sie auch mit dem Futter oder direkt ins Maul verabreicht werden. Cats and dogs may be exposed to fleas when they go outside and they can carry these back into the home. Do not contact or allow children to contact the application site until dry. In two well-controlled laboratory dose confirmation studies, one dog developed mild to moderate redness, flaking, crusts/scabs and alopecia at the treatment site from Day 1 through 14 after application of Bravecto on Day 0, and one dog developed self-limiting generalized erythema (possible allergic reaction) one day after treatment with Bravecto. Copyright © 2016, 2019 Intervet Inc, a subsidiary of Merck & Company Inc. All rights reserved. For prevention of heartworm disease, Bravecto Plus should be administered at 2-month intervals. BRAVECTO Topical Solution 500 mg Indications. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 3 Dec 2020) and others. Oral Safety Study: In a safety study, one dose of Bravecto topical solution was administered orally to 8- to 10-month-old-puppies at 1× the maximum labeled dose of 56 mg/kg. Bravecto demonstrated ≥90% effectiveness against Amblyomma americanum 72 hours post-infestation for 8 weeks, but failed to demonstrate ≥90% effectiveness beyond 8 weeks. Product may be supplied in 1 or 2 tubes per box. 1 SLEGS VIR DIEREGEBRUIK . Fluralaner is for systemic use and belongs to the class of isoxazoline-substituted benzamide derivatives. Select one or more newsletters to continue. Nr. For optimal control of tick and flea infestation, the Bravecto chewable tablet should be administered at 3 monthly intervals. Bravecto has not been shown to be effective for 12-weeks duration in puppies less than 6 months of age. xmp.did:A6150B3F132068118083C6B6E3A95A4D Bravecto Plus should be administered topically as a single dose every 2 months according to the Dosage Schedule below to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. Reported Human reactions after contact with Bravecto (Fluralaner parent chemical) Many members may not be aware there have been adverse reactions in humans after giving either the chewable or spot on. One treated animal experienced vomiting eight hours after administration. BRAVECTO Topical Solution for Dogs: The most commonly reported adverse reactions include vomiting, hair loss, diarrhea, lethargy, decreased appetite, and moist dermatitis/rash. ��, 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. Use with caution in dogs with a history of seizures or neurologic disorders. The mode of action of fluralaner is the antagonism of the ligand-gated chloride channels (gamma-aminobutyric acid (GABA)-receptor and glutamate-receptor). proof:pdf Avoid oral ingestion. Bravecto may be administered every 8 weeks in case of … Avoid contact with skin and eyes. Bravecto is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or … In well-controlled laboratory studies, Bravecto demonstrated ≥93.3% effectiveness against Dermacentor variabilis, Ixodes scapularis and Rhipicephalus sanguineus 48 hours post-infestation for 12 weeks. Cosmetic changes at the application site included matting/clumping/spiking of hair, wetness, or a greasy appearance. Fluralaner is a member of the isoxazoline class. RotisSansSerif-Light To obtain maximum flea control, it is recommended that all cats and dogs in the same environment are treated. Reproductive Safety Study: Reproductive safety was evaluated with the oral tablet formulation of fluralaner (see Clinical Pharmacology). Keep this and all drugs out of the reach of children. Not for human use. Indications: Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infes- Bravecto is a chewable tablet and is well accepted by most dogs. The fluoxetine was discontinued and the dog experienced no additional seizures during the study. PDF/X-1:2001 A second dog had a seizure 76 days after its first dose and 3 days after starting fluoxetine for separation anxiety. Bravecto Kautabletten zum oder um den Zeitpunkt der Fütterung verabreichen. The dog was started on antiepileptic medication and had no additional seizures during the study. It's as simple as that. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. In cats, Bravecto® Spot On provides 3 months of protection against fleas and ticks. Download the Bravecto ® Spot-On owners brochure below. For the treatment and prevention of tick , flea and mite infestations in dogs. 1,2,17 No adverse effects with Bravecto Chew for Dogs in MDR-1 gene-deficient collies at 3x the recommended … WARNINGS Human Warnings: Not for human use. Then speak with your vet. (see Animal Safety). default (fluralaner topical solution) for Dogs BRIEF SUMMARY (For full Prescribing Information, see package insert) Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. For topical use only. In a well-controlled U.S. field study, a single dose of Bravecto reduced fleas by ≥99.8% for 12 weeks. 2017-07-12T12:56:12-04:00 Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. :n���E{#�������:��.�A������-�쑞,��j8A/�/T�;�d�a_�$��'x�Z5������,ˍ�I�:}�vj�Y#O�F2-�X�b��˾��[\�w;��k� converted For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae. Do not store above 86°F (30°C). from application/x-indesign to application/pdf Intervet Canada Corp., subsidiary of Merck & Co., Inc., 16750, route Transcanadienne, Kirkland, QC H9H 4M7 1 866 683-7838 Version: 21FEB2019 ®Intervet International B.V. Used under license. The dogs in the control group (0X) were administered saline orally. Use caution in dogs with a history of seizures. Hold the tube at the crimped end with the cap in an upright position (tip up). The following abnormalities were noted in 7 pups from 2 of the 10 dams in only the treated group during gross necropsy examination: limb deformity (4 pups), enlarged heart (2 pups), enlarged spleen (3 pups), and cleft palate (2 pups). Bravecto® provides 12 weeks of protection against fleas and ticks in dogs with the tasty Chew. For dogs weighing more than 56 kg, use a combination of two tablets that most closely matches the body weight. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, and urinalysis), gross pathology, histopathology, or organ weights. Bravecto kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. Bravecto gives your cat protection against fleas and black-legged ticks (deer ticks) for 12 weeks, and dog ticks for 8 weeks. Copyright © 2021 Animalytix LLC. 2017-07-12T12:56:09-04:00 Bravecto Dog PI_155586 R5_8.5x11.indd Bravecto should be administered topically as a single dose every 12 weeks according to the Dosage Schedule below to provide a minimum dose of 11.4 mg/lb (25 mg/kg) body weight. Bravecto ist eine Kautablette und wird von den meisten Hunden gut angenommen. Available for Android and iOS devices. The dogs in the control group (0X) were untreated. In a well-controlled field study Bravecto was used concurrently with other medications, such as vaccines, anthelmintics, antibiotics, steroids and sedatives. Bravecto Topical Solution for Dogs kills adult fleas and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis) and the treatment and control of tick infestations [ Ixodes scapularis (black-legged tick), Dermacentor variabilis (American dog tick), and Rhipicephalus sanguineus (brown dog tick)] for 12 weeks in dogs and puppies 6 months of age and older, and … Bravecto (fluralaner topical solution) for Dogs. BRAVECTO PLUS reducesthe flea challenge experienced by the animaland aids in the treatment strategy for flea allergy dermatitis. Bravecto is not effective against lone star ticks beyond 8 weeks of dosing. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Bodyweight (kg) of dog: Bravecto 112.5 mg: Bravecto 250 mg: Bravecto 500 mg: Bravecto 1000 mg: Bravecto 1400 mg: 2* – 4.5: 1 > 4.5 – 10: 1 > 10 – 20: 1 > 20 – 40: 1 > 40 – 56: 1 *For use in dogs from 8 weeks of age and over 2kg. Each tube is packaged individually in a pouch. Bravecto ® Chew: Commonly observed adverse reactions in clinical trials (1,6 % of treated dogs) were mild and transient gastrointestinal effects such as diarrhoea, vomiting, inappetence, and drooling. Step 3: Squeeze the tube and gently apply Bravecto in one or more spots starting between the shoulder blades and continuing along the dog’s back. Place the tube tip vertically against the skin between the shoulder blades of the dog. Bravecto is also indicated for the treatment and control of Amblyomma americanum (lone star tick) infestations for 8 weeks in dogs and puppies 6 months of age and older, and weighing 4.4 pounds or greater. The chemical name of fluralaner is (±) - 4 - [5 - (3,5 - dichlorophenyl) - 5 - (trifluoromethyl) - 4,5 - dihydroisoxazol - 3 - yl] - 2 - methyl - N - [2 - oxo - 2 - (2,2,2 - trifluoroethylamino) ethyl]benzamide. Dosage and Administration: Bravecto should be administered orally as a single dose every 12 weeks according to the Dosage Schedule Administer Bravecto chewable tablets at or around the time of feeding. Each tube is formulated to provide a minimum dose of 11.4 mg/lb (25 mg/kg) body weight. It contains fluralaner as a long-acting insecticide to not only kill but also help break the life cycle. / Bravecto is not effective against Amblyomma americanum ticks beyond 8 weeks after dosing (see Effectiveness). The bioavailability of fluralaner following oral and topical administration is approximately 25%. Convulsions and lethargy have been reported very rarely in spontaneous (pharmacovigilance) reports. Bravecto® provides 12 weeks of protection against fleas and ticks in dogs with the tasty Chew. Bravecto is also designed to eliminate fleas in as little as 8 hours. For a copy of the Safety Data Sheet (SDS) or to report suspected adverse drug events, contact Merck Animal Health at 1-800-224-5318. Avoid contact with skin and eyes. *Dogs over 123.0 lb should be administered the appropriate combination of tubes. Ships Free . >20 -40 BRAVECTO 1000 MG FLURALANER Chewable Tablets for Large Dogs >40 -56 BRAVECTO 1400 MG FLURALANER Chewable Tablets for Very Large Dogs Within each weight range, a whole tablet must beused. PDF/X-1a:2001 The cap is designed to stay on the tube for dosing and should not be removed. Part the fur at the administration site. Avoid oral ingestion. In dogs older than 8 weeks, treatment every 2 months has been shown to be well … Watch the slide show to learn how easy it is to apply FRONTLINE Plus onto your pet. 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